COURS PHYSIOLOGIE RENALE PDF

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We'd like to understand how you use our websites in order to improve them. Register your interest. The glomerular filtration rate GFR and the renal blood flow RBF correspond to the filtered volume by the kidneys and the blood volume delivered by the renal arteries per unit of time, respectively. A better understanding of renal physiology is needed to delineate the impact of modifications in renal hemodynamics on GFR.

In animals, at the early stages of sepsis, GFR is correlated with cardiac output. In contrast, at later stages, a decline in GFR is observed in animals and humans along with the development of renal vascular damage. The complexity of the mechanisms involved in the relationship between GFR and RBF and the progression in this relationship over time likely explains the repeated failures of hemodynamic interventions in rescuing renal function after end-organ insult.

This is a preview of subscription content, log in to check access. N Engl J Med — SvO 2 Collaborative Group.

Kidney 9th Ed. Google Scholar. Physiol Rev — Plasma-flow dependence of GFR. Am J Physiol — Johnson PC Autoregulation of blood flow. Circ Res — Navar LG Renal autoregulation: perspectives from whole kidney and single nephron studies. Am J Physiol F—F Kidney Int — Curr Opin Nephrol Hypertens — Schnermann J, Briggs JP Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice. Edwards RM Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels.

Myers SI, Turnage RH, Hernandez R, et al Autoregulation of renal and splanchnic blood flow following infra-renal aortic clamping is mediated by nitric oxide and vasodilator prostanoids. J Cardiovasc Surg Torino — Burban M, Hamel JF, Tabka M, et al Renal macro- and microcirculation autoregulatory capacity during early sepsis and norepinephrine infusion in rats. Crit Care Lond Engl R Chest — Ann Surg — Brenner M, Schaer GL, Mallory DL, et al Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter.

Crit Care Med — Benes J, Chvojka J, Sykora R, et al Searching for mechanisms that matter in early septic acute kidney injury: an experimental study. A study of the reperfused renal allograft. J Clin Invest — Badin J, Boulain T, Ehrmann S, et al Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study.

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Lancet — Mullens W, Abrahams Z, Francis GS, et al Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol — Legrand M, Dupuis C, Simon C, et al Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study.

Boyd JH, Forbes J, Nakada T, et al Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Mohmand H, Goldfarb S Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome. Download references. Correspondence to N. Reprints and Permissions.

Beloncle, F. Download citation. Received : 26 March Accepted : 05 May Published : 14 June Issue Date : July Search SpringerLink Search. Abstract The glomerular filtration rate GFR and the renal blood flow RBF correspond to the filtered volume by the kidneys and the blood volume delivered by the renal arteries per unit of time, respectively.

Radermacher Authors F. Beloncle View author publications. You can also search for this author in PubMed Google Scholar. View author publications. Rights and permissions Reprints and Permissions. About this article. Cite this article Beloncle, F.

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