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Montecillo, Texcoco, Edo. The taxoids are polioxigenated diterpenes from the metabolic pathway of the 2-methyl-erythritol 4-phosphate whose biosynthesis is generated in the plastides. The importance of the taxoides including taxol, in the area of human medicine is very valuable due to the use in oncology, drug used against breast, lung and ovarian cancer.

Abbasi K. Investigation of the effects of basal medium type on the production of anti-cancer drug taxol from cell culture of Taxus baccata L. Journal of Plant Biology.

Agrawal S. Kumar S. Isolation of taxoids from cell suspension cultures of Taxus wallichiana. Planta Med. Arias M. Ashton A. Scholarly Edition. McGraw-Hill, Interamericana. Baebler S.

Establishment of cell suspension cultures of yew Taxus x media Rehd. In vitro Cel. Baloglu E. Synthesis and biological evaluation of paclitaxel analogs.

Phd Thesis. Virginia polytechnic institute and state university USA. Barrales C. Revista la Ciencia y el Hombre. Luna P. Spanish Journal of Rural Development. Barrios H. Increase of taxol production in Taxus globosa Shoot callus by Chlorocholine Chloride. The Open Natural Products Journal. Burgarella C. Recent population decline and selection shape diversity of taxol-related genes.

Molecular Ecology. Brunakova K. Selection of callus cultures of Taxus baccata L. Engineering in Life Sciences. Centelles J. Correa M. Scientia Et Technica. Cragg G.

The taxol supply crisis. Journal of Natural Products. Cusido R. Bonfill M. Source of isopentenyl diphosphate for taxol and baccatin III biosynthesis in cell cultures of Taxus baccata.

Biochemical Engineering Journal. Chau M. Archives of Biochemistry and Biophysics. Edahiro J. Pheylpropanoid metabolite supports cell agregate formation in strawberry cell suspension culture. Journal of Bioscience and Bioengineering. Eisenreich W. Multiple oxigenase reactions in the biosynthesis of taxoids. Journal of the American Chemical Society. Simultaneous determination of main taxoids in Taxus needles extracts by solid-phase extraction-high-performance liquid chromatography with pentafluorophenyl column.

Biomedical Chromatography. Gibson, D. Potential of plant cell culture for taxane production. Suffness M. Taxol science and applications CRC Press. Gibson D. Initiation and growth of cell lines of Taxus brevifolia Pacific yew. Plant Cell Reports. Jha S. Planta Medica. Jin H. Molecular Biology. Jong M. Elicitation kinetics of taxane production in suspension cultures of Taxus baccata Pendula.

Biotechnology Techniques. Hansen R. Taxus populations and clippings yields at commercial nurseries. Journal of Environmental Horticulture. Hara T. Paclitaxel production by immobilized cell suspension cultures of Taxus cuspidata var. Hezari M. Purification and characterization of taxa-4 5 ,11 12 -diene synthase from pacific yew Taxus brevifolia that catalyzes the first committed step of taxol biosynthesis. Holmes F. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer.

Journal of the National Cancer Institute. Hung Sh. Hydrogen peroxide functions as a stress signal in plants. Bot Bull. Jennewein S. Cytochrome p taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.

Taxol biosynthesis taxane 13 alpha-hydroxylase is a cytochrome pdependent monoxygenase. Kaspera R. Cytochrome P oxygenases of taxol biosynthesis.

Phytochemistry Reviews. Ketchum R. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate.

Khosroushahi, A. Improved Taxol production by combination of inducing factors in suspension cell culture of Taxus baccata. Cell Biology International. Kim, B. Effect of the plant peptide regulator, phytosulfokine-alpha, on the growth and taxol production from Taxus sp.

Biotechnology and Bioengineering. Kim J. Production of taxol and related taxanes in Taxus brevifolia cell cultures: effect of sugar. Biotechnology Letters. Kim, S.


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