MACROLIDOS PDF

Introduction: Community-acquired pneumonia CAP is a global disease responsible for a large number of deaths, with significant economic impact. As diagnostic tools have increased in sensitivity, understanding of the etiology of CAP has begun to change. Mycoplasma pneumoniae is one of the major pathogens causing CAP. Macrolides and related antibiotics are first-line treatments for M.

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Introduction: Community-acquired pneumonia CAP is a global disease responsible for a large number of deaths, with significant economic impact. As diagnostic tools have increased in sensitivity, understanding of the etiology of CAP has begun to change.

Mycoplasma pneumoniae is one of the major pathogens causing CAP. Macrolides and related antibiotics are first-line treatments for M. Macrolide resistance has been spreading for 15 years and now occurs in worldwide. We undertook the first study on macrolide resistance of M. This may be helpful to determine the appropriate therapy for CAP in this population. Objective: To investigate the rate and mechanism of macrolide resistance in Yantai.

Methods: Pharyngeal swab samples were collected from adult CAP patients. Samples were assayed by polymerase chain reaction PCR and cultivated to test for M. Nested PCR was used to specifically amplify M. Results were confirmed by sequencing. Twenty-seven strains of M.

Results: Out of samples tested, 27 were positive for M. The mechanism of macrolides resistance was AG point mutation in the sequence directly binding to macrolides in the 23S rRNA V domain in vitro. The mean pyretolytic time for the fluoroquinolone group was 4. Conclusions: Macrolides are not the first-line treatment for M. Nosotros realizamos el primer estudio de resitencia a M. Se aislaron 27 cepas de M. Resultados: De muestras, 27 fueron positivas para M.

Keywords: Mycoplasma pneumoniae; adult; community-acquired pneumonia; drug resistance; therapy. Conflicts of interest The authors declare no conflict of interest.

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Full-text links Cite Favorites. Abstract in English , Spanish. Conflict of interest statement Conflicts of interest The authors declare no conflict of interest. Similar articles [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. Yin YD, et al. PMID: Chinese. Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia. Miyashita N, et al. BMC Infect Dis. Choi JH, et al.

Microb Drug Resist. Epub Nov PMID: Overview of antimicrobial options for Mycoplasma pneumoniae pneumonia: focus on macrolide resistance. Cao B, et al. Clin Respir J. Epub Oct PMID: Review. Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. Morozumi M, et al. J Infect Chemother.

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Chin Med J Engl ;— High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis. Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia a review of the japanese literature. MeSH terms Adolescent Actions. Adult Actions.

Aged Actions. Female Actions. Humans Actions. Male Actions. Middle Aged Actions. Point Mutation Actions. Polymerase Chain Reaction Actions. Young Adult Actions. Substances Anti-Bacterial Agents Actions. Macrolides Actions. Copy Download.

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