We report a case of Hymenolepis diminuta infection in a 2-year-old child living in a suburban area of Catania, Italy. This case was initially referred to us as Dipylidium caninum infection, which was not cured after being treated twice with mebendazole. However, by analyzing the clinical presentation and stool samples we arrived to the diagnosis of H. The case presented with atypical allergic manifestations which had never been reported as clinical features of symptomatic H. The patient was treated with a 7-day cycle of oral niclosamide, which proved to be safe and effective. This case report emphasizes that a correct parasitological diagnosis requires adequate district laboratories and trained personnel.
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We report a case of Hymenolepis diminuta infection in a 2-year-old child living in a suburban area of Catania, Italy. This case was initially referred to us as Dipylidium caninum infection, which was not cured after being treated twice with mebendazole. However, by analyzing the clinical presentation and stool samples we arrived to the diagnosis of H.
The case presented with atypical allergic manifestations which had never been reported as clinical features of symptomatic H. The patient was treated with a 7-day cycle of oral niclosamide, which proved to be safe and effective.
This case report emphasizes that a correct parasitological diagnosis requires adequate district laboratories and trained personnel. In addition, we recommend the importance of reporting all H. Directory of Open Access Journals Sweden. Hymenolepis diminuta infection in a young boy from rural part of Northern India. Full Text Available Hymenolepis diminuta H. Humans are infected by eating meal contaminated with these arthropods.
This infection is not seen commonly in Indian population. We present here a case report of infection with H. Effects of ultraviolet light on Hymenolepis diminuta ova and cysticercoids. The ova and cysticercoids of Hymenolepis diminuta were exposed to a A wave length of ultraviolet light for various time periods. Development was extremely impaired in the cysts which had been irradiated for 30 and 60 minutes. When these were administered to the final host no tapeworms developed.
From intermediate host beetle larvae fed with irradiated ova, only three cysticercoids were recovered.
Development was impaired in both cases and the infective rate of irradiated ova and cysts of the least exposed groups was lower than that of the controls.
Niclosamide as a treatment for Hymenolepis diminuta and Dipylidium caninum infection in man. In the 5-year period , 43 patients infected with Dipylidium caninum and 43 patients infected with Hymenolepis diminuta were treated with Yomesan niclosamide in the dosages recommended by the Parasitic Disease Drug Service, Center for Disease Control.
The first post-treatment stool specimen and 1-week and 3-month specimens were examined in 13 patients with D. Two patients with persistent H. Four of these cases had been unresponsive to an initial course of quinacrine hydrochloride. Thus, niclosamide seems to be an effective, relatively nontoxic drug for the initial therapy of these cestode infections. Full Text Available Cestodiases are common parasitic diseases of animals and humans.
As cestodes have complex lifecycles, hexacanth larvae, metacestodes including cysticercoids, and adults produce proteins allowing them to establish invasion and to survive in the hostile environment of the host.
Hymenolepis diminuta is the most commonly used model cestode in experimental parasitology. The aims of the present study were to perform a comparative proteomic analysis of two consecutive developmental stages of H.
Somatic proteins of H. Cysticercoids were obtained from experimentally infected beetles, Tenebrio molitor, whereas adult worms were collected from experimentally infected rats. The identified proteins were classified according to molecular function, cellular components and biological processes. Our study showed a number of differences and similarities in the protein profiles of cysticercoids and adults; cysticercoid and adult proteins were identified.
From these proteins, were present only in the cysticercoid and 80 only in the adult stage samples. Both developmental stages shared proteins; among which six represented immunomodulators and one is a potential drug target. Possible roles and functions of proteins identified with both proteomic approaches are discussed. Impairment of the chemical defence of the beetle, Tenebrio molitor, by metacestodes cysticeroids of the tapeworm, Hymenolepis diminuta.
The defensive glands of beetles, Tenebrio molitor, infected with metacestodes cysticercoids of Hymenolepis diminuta are everted less frequently upon stimulation, and contain less toluquinone methylbenzoquinone and m-cresol, than glands of uninfected controls. These differences, as shown in predation trials with wild rats, increase the likelihood that both cysticercoids and beetles will be ingested by the tapeworm's definitive host. This is the first documented case of a parasite inhibiting the chemical defence of an intermediate host, and one of only a few reports of parasite-induced manipulation of host biology supported by empirical evidence implicating facilitated parasite transmission between host species.
Hymenolepis diminuta is a cestod of rodents and rarely infects humans. Infection in humans is via ingestion of infected insects. This study was aimed to detect H. The red flour beetles and cockroaches were collected from local bakeries in five cities including Tehran, Ahvaz, Kazerun, and Sabzevar during Some beetles and cockroaches were colonized in insectary and adults from F1 generation were fed on H.
Both laboratory-infected and field-collected samples were dissected and examined for cysticercoids. Detection of H. Except the beetles from Ahvaz, all specimens were negative for cysticercoid by microscopy. Of the four dissected beetles from Ahvaz, one harbored 12 cysticercoids. None of the cockroaches was infected. Two beetles from Ahvaz, including the remainder of the microscopic positive specimen, yielded the expected amplicon in PCR assay.
The H. Lack of infection in the majority of beetles may reflect a low rat infestation rate in those areas, alternatively, the examined specimens might not have been the representative samples of the T.
A confocal microscopy-based atlas of tissue architecture in the tapeworm Hymenolepis diminuta. Tapeworms are pervasive and globally distributed parasites that infect millions of humans and livestock every year, and are the causative agents of two of the 17 neglected tropical diseases prioritized by the World Health Organization.
Studies of tapeworm biology and pathology are often encumbered by the complex life cycles of disease-relevant tapeworm species that infect hosts such as foxes, dogs, cattle, pigs, and humans. Thus, studies of laboratory models can help overcome the practical, ethical, and cost-related difficulties faced by tapeworm parasitologists.
The rat intestinal tapeworm Hymenolepis diminuta is easily reared in the laboratory and has the potential to enable modern molecular-based experiments that will greatly contribute to our understanding of multiple aspects of tapeworm biology, such as growth and reproduction.
As part of our efforts to develop molecular tools for experiments on H. Using confocal microscopy, we have assembled an "atlas" of H. The methodologies we describe will facilitate characterization of loss-of-function perturbations using H. This toolkit will enable a greater understanding of fundamental tapeworm biology that may elucidate new therapeutic targets toward the eradication of these parasites.
Published by Elsevier Inc. All rights reserved. Full Text Available El objetivo del estudio fue determinar si Ulomoides dermestoides se comporta como hospedero intermediario de Hymenolepis diminuta , por lo que cien de ellos se infectaron experimentalmente con huevos del cestodo. Full Text Available Background: Hymenolepis diminuta is a cestod of rodents and rarely infects humans.
Methods: The red flour beetles and cockroaches were collected from local bakeries in five cities including Tehran, Ahvaz, Kazerun, and Sabzevar during — Results: Except the beetles from Ahvaz, all specimens were negative for cysticercoid by microscopy.
Conclusion: Lack of infection in the majority of beetles may reflect a low rat infestation rate in those areas, alternatively, the examined specimens might not have been the representative samples of the T. Full Text Available Parasite effects on host fitness and immunology are often intensity-dependent. Unfortunately, only few experimental studies on insect-parasite interactions attempt to control the level of infection, which may contribute substantial variation to the fitness or immunological parameters of interest.
The tapeworm Hymenolepis diminuta—flour beetle Tenebrio molitor model—has been used extensively for ecological and evolutionary host—parasite studies. Successful establishment of H. Like in other insect models, there is a lack of standardization of the infection load of cysticercoids in beetles. The aims of this study were to: 1 quantify the relationship between exposure dose and establishment success across several H.
Different egg concentrations of H. We found that the establishment of cysticercoids in relation to exposure dose could be accurately predicted using a power function where establishment success was low at three lowest doses and higher at the two highest doses tested. Long-term starvation had a negative effect on cysticercoid establishment success, while insertion of a nylon filament and wounding the beetles did not have any effect compared to control treatment. Thus, our results show that parasite load may be predicted from the exposure dose within the observed range, and that the relationship between dose and parasite establishment success is able to withstand some changes in host body condition.
Parasite effects on host fitness and immunology are often intensity-dependent. Alteration of the rat cecal microbiome during colonization with the helminth Hymenolepis diminuta. The microbiome is now widely recognized as being important in health and disease, and makes up a substantial subset of the biome within the ecosystem of the vertebrate body.
At the same time, multicellular, eukaryotic organisms such as helminths are being recognized as an important component of the biome that shaped the evolution of our genes. The absence of these macroscopic organisms during the early development and life of humans in Western culture probably leads to a wide range of human immunological diseases. However, the interaction between the microbiome and macroscopic components of the biome remains poorly characterized.
In this study, the microbiome of the cecum in rats colonized for 2 generations with the small intestinal helminth Hymenolepis diminuta was evaluated. The introduction of this benign helminth, which is of considerable therapeutic interest, led to several changes in the cecal microbiome. The results point toward ecological relationships between various components of the biome, with the observed shifts in the microbiome suggesting potential mechanisms by which this helminth might exert therapeutic effects.
Analysis of lead pollution levels within an urban ecosystem using the cestode Hymenolepis diminuta and its rat hosts as bioindicators. The overall goal of this study was to use the Rattus spp. Rats of the genus Rattus were collected from three shanty towns and three residential neighbourhoods of the city of Buenos Aires.
Concentrations of lead in the livers of wild rats and in their parasite H. The landscape unit and tissue type had a significant effect on lead concentration, being higher in residential neighbourhoods as well as in H. Nevertheless, no significant differences were found for the mean lead concentration in livers between uninfected and infected rats.
Since the available information describing heavy-metal pollution within the city of Buenos Aires is scarce, the results of this study allow us to update data about the extent of biologically available lead contamination.
Considering that rats and H. Infection increases the value of nuptial gifts, and hence male reproductive success, in the Hymenolepis diminuta -Tenebrio molitor association.
During copulation, male insects pass accessory gland components to the female with the spermatophore. These gifts can affect female reproductive behaviour, ovulation and oviposition.
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